BACKGROUND The major health problem of the country, Ethiopia has been largely preventable communicable diseases and nutritional disorders. Breast and cervical cancer is the primary non infectious disease following hypertension and diabetes. Breast and cervical cancers are public health problem and the most common cause of cancer deaths among women in developed or developing countries. However there is no adequate information regarding magnitude and associated risk factors of breast and cervical cancer in Ethiopia. This study identifies the magnitude and associated risk factors of breast and cervical cancer and some useful input for National Health Care Service. General Objective To assess the magnitude of breast and cervical cancer and associated risk factors for breast cancer in Addis Ababa, Tikur Anbessa Specialized referral hospital from March1/2013-april 15/2013. Methodology Cross-sectional study of retrospective secondary data and case control study were conducted in Addis Ababa, Tikur Anbessa Specialized referral Hospital. Result Breast and cervical cancers cross-sectional retrospective data were 753 and case control directly collected from cancer radiotherapy department and Gyn/Obs department were 357 included in the study. The mean age for breast cancer was 47.6 years with Sd 14.1, minimum age 15 years and maximum was 99 years and cervical cancer mean age 51.6 years with Sd 12.8 minimum age 20 and maximum 92 years. The incidence rate of breast cancer was 28.4 from 100,000 female and 15.7 from 100,000 female for cervical cancer. The breast cancer incidence was very high among A.A city dwellers. The body mass index of participants above 25.1kg/m2 4.6 times (AOR= 4.643 (95% Cl: 1.819, 12.896) more likely affected than body mass index less 25.1kg/m2.Age 50 years and above 6 time (AOR=6.003 (95% CI: 2.606, 13.830) more likely affected than lower age groups. Conclusion Incidence of breast cancer in Addis Ababa city was higher, which is needed more health check up and intervention. Ministry of health should have set clinical and self breast examination and cervical screening every six month for all age above 40 yrs, BMI greater than 25.1kg/m2 and those live in rented house.